Cisplatin is used together with other medications to treat bladder cancer, testicular cancer, or ovarian cancer. Ensure adequate flushing of the eyes by separating the eyelids with fingers. You have selected the maximum number of product attributes 3 to compare. Introduction cisdiaminedichloroplatinum ii cisplatin is a major antineoplastic drug widely used in the treatment of several malignancies1,2. Cisplatin fda prescribing information, side effects and uses. The following side effects are common occurring in greater than 30% for patients taking cisplatin. Online idms was applied for accurate, species unspecific quantification. Use is contraindicated in those patients with a history of allergic reaction to cisplatin or other platinum containing compounds, or any component of the formulation. Overview this sample consists of a simple form containing four distinct fields. Jun 01, 2015 cisplatin injection is a clear, lightyellow, sterile aqueous solution available in amber vials containing 1 mgml of cisplatin. Peyrone in 1844 and its chemical structure was first elucidated by. May 28, 2019 hypersensitivity to cisplatin or to any of the excipients listed in section 6. Forms inter and intrastrand dna adductscrosslinks, consequently blocking dna replication and transcription and inducing cell death 2, 12, 15.
Find documents on drug safety and administration for healthcare providers, including calculations. Platinol cisplatin for injection side effects, images. Accidental release measures contain spill and collect, as appropriate. Cisplatin cas 15663271, is a platinum coordination complex with potent antineoplastic activity. Numerous mechanisms of cisplatin resistance were described including changes in cellular uptake, drug efflux, increased detoxification, inhibition of apoptosis and increased dna repair. Cisplatin 1 mgml sterile concentrate should be diluted in 2 litres of 0. It has been widely accepted because of its potent cytotoxic effects on a variety of tumor types including testicular, ovarian, and cervical carcinoma3. The first step in the process after the cisplatin molecule penetrates the cell membrane intact is for a molecule of water to. Many people living with cancer experience nausea, diarrhea and other symptoms from their treatment or disease.
Only select registry of toxic effects of chemical substances rtecs data is presented here. Mar 06, 2018 what is cisplatin platinol, platinol restricted access, platinolaq. In order to for patients to be treated as a day case, the regimens have been modified as follows. Cisplatin dosing, indications, interactions, adverse effects.
Carboplatin therapy is associated with a low rate of transient serum aminotransferase elevations and with rare instances of clinically apparent liver injury. See actual entry in rtecs for complete information. Read complete cisplatin msds ciswel manufactured by getwell oncology a leader manufacturing complex oncology generics in india. We have tried to make it as accurate and useful as possible, but can take no responsibility for its use, misuse, or accuracy.
Platinumii diammine dichloride, cisplatin synonyms. Carboplatin is an intravenously administered platinum coordination complex and alkylating agent which is used as a chemotherapeutic agent for the treatment of various cancers, mainly ovarian, head and neck and lung cancers. The spectrum shows three maxima at 203 nm, 301 nm, and 362 nm, a shoulder at 285 nm, and minima at 246 nm and 348 nm. May use concomitant amifostine to decrease nephrotoxicity. Sds of cisplatin, safety data sheets, cas 15663271 chemblink. During all fire fighting activities, wear appropriate protective equipment, including self contained breathing apparatus. Ciswel, cisplatin injection, cisplatin manufacturer, cisplatin manufacturer in india, cisplatin price in india, cisplatin cost in india, cisplatin cost effective option,cisplatin msds created date. Cisplatin was the first member of a class of anticancer drugs, which now include carboplatin sc202093 and oxaliplatin sc202270, that form dna adducts resulting in apoptosis. Hazardous ingredient ww% cas number pinumber 1017 manufacturers name chemco manufacturing. Identification of the substancepreparation and the companyundertaking material name. Hci andor sodium hydroxide added to adjust ph to 3. Cisplatin was discovered in 1845 by michele peyrone but its biological property was hidden until 1965 when a. Higher doses of cisplatin are being given in daycare, increasing the strain on the chemotherapy suites and pharmacy. Cisplatin is generally synthesised by the ammonolysis of potassium tetrachloroplatinate k 2 ptc1 4.
Cisplatin 1 mgml sterile concentrate summary of product. Induces apoptosis in cancer cells, possibly via caspase3 activation. Immediately flush eyes with plenty of water for at least 15 to 20 minutes. Incidence of cisplatin induced ototoxicity in adults with. The physical and chemical stability of cisplatin teva in. Cisplatin injection cisplatin injection cisplatin cisplatin injection injection is a sterile aqueous solution, available in 50, 100 and 200 ml multiple dose vials, each ml containing 1 mg of cisplatin cisplatin injection and 9 mg sodium chloride in water for injection. Accelio present applied technology created and tested using.
Cisplatin offers may be in the form of a printable coupon, rebate, savings card, trial offer, or free samples. Cisplatin hydration for outpatients chemotherapy regimen. Sheet provided by the manufacturer that summarizes the chemical prop. Do not handle until all safety precautions have been read and understood. Each 50 ml or 100 ml amber vial of infusion concentrate contains. The information included in this section describes the potential hazards of the individual ingredients. Cisplatin investigated as a drug, mutagen, natural product, reproductive effector, and tumorigen.
Cisplatin dosing, indications, interactions, adverse. The cleaning protocol that consists of peridox rtu cleaner and 70% ipa isopropyl alcohol prewetted wipers has shown to remove at least 99. Peyrone in 1844 and its chemical structure was first elucidated by alfred werner in 1893. A study of their pharmacokinetics and importance in the nephrotoxic and antitumour activity of cisplatin. Before research use of highly toxic chemicals, please complete this form and have it approved by your supervisor. Mar 01, 2019 cisplatin, the active ingredient in cisplatin for injection, usp, is a yellow to orange crystalline powder with the molecular formulacl 2 h 6 n 2 pt and a molecular weight of 300. Should be administered only by or under the direct supervision of a qualified physician who is experienced in the use of cancer chemotherapeutic agents. All testing was performed using 316 stainless steel as the substrate surface.
Anderson cancer center, 1515 holcombe boulevard, houston, tx 770304009, usa cisplatin is one of the most potent antitumor agents. What is cisplatin platinol, platinol restricted access, platinolaq. The disproportionate accumulation of cisplatin in kidney tissue contributes to cisplatin induced nephrotoxicity. The cisplatin concentration in proximal tubular epithelial cells is about 5 times the serum concentration.
These cotton glove samples were then analyzed for cisplatin. See chemotherapy nephrotoxicity and dose modification in patients with kidney impairment. As is discussed at length in other contributions to. Cisplatin cisplatin dose, indications, adverse effects. Nov 20, 2012 cisplatin cisdiamminedichloroplatinum, cispt is a nonorganic complex, where the central atom is divalent platinum. Quantification of cisplatin, carboplatin and oxaliplatin in spiked human plasma samples by icpsfms and hydrophilic interaction liquid chromatography hilic combined with icpms detection. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy.
The drug is also sometimes used offlabel to treat head and neck cancers. Cisplatin may give allergic reactions in some patients. The molecular formula of cisplatin is cl2h6n2pt mw 300. Cisplatin can cause severe bone marrow suppression with fatalities due to infection. There is no relationship between the presence or severity of cisplatin side effects and effectiveness of cisplatin. Each 50 ml, 100 ml or 200 ml amber vial of cisplatin injection contains. Cisplatin, mono and diaquacisplatin were measured in aquatic samples and in diluted urine of a cancer patient by hplcicpms. No cisplatin was detected in any ga air samples mdc 0. H300, h318, h350 for the full text of the h statements mentioned in this section, see section 16. We work hard to ensure that we are fully uptodate with regulations, and make sure to incorporate changes as soon as they occur, so that you do not risk having outofdate safety data sheets. Show this safety data sheet to the doctor in attendance. What niosh did we evaluated the facility on may 1112, 2009. The disproportionate accumulation of cisplatin in kidney tissue contributes to. Appropriate management of therapy and complications is.
The antineoplastic activity of the compound is conditioned by the spatial layout of chlorine atoms in cis position. Other companies are charging thousands of dollars to set up accounts and give you access to their msds. Cspm2 hydration protocol for cisplatin chemotherapy. Platinol cisplatin for injection side effects, images, uses. This information was last updated on september 5, 2003. Platinol cisplatin for injection, usp should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. We took wipe samples and area and personal breathing zone air samples for cisplatin.
Cisplatin side effects, dosage, interactions drugs. Several payment sources exist for cancer drugs in ontario, depending on the drug, disease indication, and how and where it is delivered. These solutions are stable up to 24 hours at room temperature. To minimize cisplatin resistance, combinatorial therapies were developed and have proven more effective to defeat cancers. Dec 31, 2019 cisplatin injection is a clear, colorless, sterile aqueous solution. Some offers may be printed right from a website, others require registration, completing a questionnaire, or obtaining a sample from the doctors office. Cisplatin cas 15663271 scbt santa cruz biotechnology. Inclusion criteria were 1 cisplatin as the primary chemotherapeutic agent and 2 hearing evaluation performed prior. Cisplatin injection is a clear, lightyellow, sterile aqueous solution available in amber vials containing 1 mgml of cisplatin. Cytotoxic evaluation of cisplatin, cisplatinhydroxypropyl. Cytotoxic evaluation of cisplatin, cisplatinhydroxypropyl b.
Each vial of platinol contains 50 mg cisplatin, 450 mg sodium chloride, usp, and 500 mg mannitol, usp. The antitumor properties of platinumcontaining drugs are attributable in large measure to the kinetics of their ligand displacement reactions. Cisplatin is compatible in solutions containing an adequate amount of chloride ions and is incompatible with solutions having low concentrations of these ions. Examples safety data sheet sds msds here you can see examples of safety data sheets in some of the various languages we handle. Cisplatin is a medicine used alone or with other therapies to treat cancer of the testicles, ovaries, or bladder. Pdf bookmark sample page 1 of 4 pdf bookmark sample sample date. To elucidate the incidence of cisplatin induced ototoxicity in adult patients, with a focus on an adult population. Cisplatin is a heavy metal complex containing a central atom of platinum surrounded by two chloride atoms and two ammonia molecules in the cis position.
Jul 18, 2017 cisplatin injection cisplatin injection cisplatin cisplatin injection injection is a sterile aqueous solution, available in 50, 100 and 200 ml multiple dose vials, each ml containing 1 mg of cisplatin cisplatin injection and 9 mg sodium chloride in water for injection. The first metal based anticancer drug sciencedirect. Monitor complete blood counts before initiating therapy, prior to each new cycle, and as clinically indicated. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Formation of toxic gases is possible during heating or fire. Original vials of cisplatin injection 1 mgml, teva were stored at room temperature. Cisplatin is one of the best and first metalbased chemotherapeutic drugs see fig. Cisplatin injection infusion concentrate is a clear, colorless, sterile aqueous solution available in amber vials. Sigmaaldrich offers a number of cisplatin products. The use of cisplatin in patients with preexisting kidney dysfunction and the renal effects of the platinum analogs, carboplatin and oxaliplatin, are discussed elsewhere. Cisplatin injection is a clear, colorless, sterile aqueous solution. The active ingredient, cisplatin, is a yellow to orange crystalline powder with the molecular formula ptcl. Mechanism of action cisplatin is believed to kill cancer cells by binding to dna and interfering with its repair mechanism, eventually leading to cell death.
Oct 05, 2014 cisplatin has a molecular weight of 301. Safe handling of hazardous chemotherapy drugs in limited. Disclaimer the sds samples above are collected from the internet by chemblink and displayed here for the tutorial purpose only. Cisplatin hydration guidelines for outpatients introduction there is increasing demand to treat more patients as outpatients.
Evaluation of exposures to healthcare personnel from. Sep 05, 2014 register now and get a free online msds binder. Cisplatin is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body. The chemistry of cisplatin in aqueous solution springerlink. Pharmaceutical division cisplatin injection safety data sheet sds effective date. There are many options to help minimize or prevent the side effects of cisplatin.
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